Palmitoylethanolamide (PEA) for the reduction of fibromyalgia
Palmitoylethanolamide is a glial cell modulator. Glial cells are Central Nervous System cells which release many inflammatory substances that act upon neurons, amplifying pain (Watkins and Maier, 2002). With time, PEA modulates (or tones down) pain.
PEA is well tolerated with no side effects and is very helpful for neuropathic pain, headache and osteoarthritis. It is anti-inflammatory and neuro-protective.
PEA is a food supplement based on a natural fatty-acid like compound, found in eggs and milk. The substance Palmitoylethanolamide (PEA) is a physiologically active molecule that the body produces naturally in small amounts:
Take 1 capsule daily at 8 pm for 3 days, then 1 capsule twice a day (8 am and 8 pm) for 3 days, then go up to 3 capsules a day (one at 8 am and two at 8 pm), most people need 4 x 300mg per day (two at 8am and 8pm). Take with or after food, or sprinkle or mix the contents of the capsule on your food.
In the case of severe pain, migraine etc. it is recommended that the capsule be opened and the contents (PEA) placed under the tongue for a few minutes. The PEA dissolves in the mouth and is absorbed sublingually.
If there is no improvement in pain intensity after a month then the daily amount taken can be doubled. Doses up to 16 capsules (100mg/kg body weight/day) can be taken.
PEA may take time to reduce pain and maximum pain reduction may take up to 3 months.
Compare the effect of Palmitoylethanolamide (PEA) versus ibuprofen, which is a nonsteroidal anti-inflammatory drug (NSAID) used for pain relief in the temporo-mandibular joint (TMJ), osteoarthritis or arthralgia. Pain decreases after 1 to 2 weeks of treatment is better with PEA than ibuprofen.
Palmitoylethanolamide (PEA) has been demonstrated to bind to a receptor in the cell nucleus. PEA performs a great variety of biological functions related to chronic and neuropathic pain and inflammation, as demonstrated in clinical trials. These include peripheral neuropathies such as diabetic neuropathy, chemotherapy-induced peripheral neuropathy, carpal tunnel syndrome, sciatic pain, osteoarthritis, low back pain, failed back surgery syndrome, dental pains, neuropathic pain in stroke and multiple sclerosis, chronic pelvic pain, post-herpetic neuralgia, and vaginal pains.
As PEA is an endogenous modulator as well as a compound in food, such as eggs and milk, no serious side effects have been reported, nor have any drug-drug interactions been reported.
PEA has been used by over a million people, showing the potential efficacy and safety in the treatment of various syndromes associated with chronic pain that is poorly responsive to standard therapies.
It can be used synergistically with other pain treatments and has been shown to reduce the reliance on opioid analgesics.
Other benefits:
Reference:
Palmitoylethanolamide, a neutraceutical, in nerve compression syndromes: efficacy and safety in sciatic pain and carpal tunnel syndrome by Keppel Hesselink Jan M, Kopsky David J, J Pain Res, 2015; 8: 729–734.
Acknowledgement: Painless clinic
Available for purchase
Painless Clinic: Unit 5,136 Railway St Cottesloe 1300 429 411
Fremantle Central Compounding Pharmacy: 1 Queen St & Cantonment St, Fremantle WA 6160 Phone: (08) 93352786
All 777 Compounding Pharmacies (Please note all other 777 pharmacies will supply within 48hours)
Captain Stirling Highway Compounding Pharmacy: 90 Stirling Hwy, Nedlands. WA Ph: (08) 9386 3380
Oxford Compounding Chemist: 73 Angove St, North Perth WA 6006 Phone: (08) 9225 9400
Pharmacy Help Mandurah Inside Peel Health: 110 Lakes Rd Mandurah 6210 Phone: (08) 95814833
Albany: Chester Pass Albany 160 Chester Pass Rd, Albany, WA, 6330 P: (08) 9841 3841
Queensland: The compounding lab: Email: enquiries@compoundinglab.com.au Phone: (07) 3862 6000
Palmitoylethanolamide is a glial cell modulator. Glial cells are Central Nervous System cells which release many inflammatory substances that act upon neurons, amplifying pain (Watkins and Maier, 2002). With time, PEA modulates (or tones down) pain.
PEA is well tolerated with no side effects and is very helpful for neuropathic pain, headache and osteoarthritis. It is anti-inflammatory and neuro-protective.
PEA is a food supplement based on a natural fatty-acid like compound, found in eggs and milk. The substance Palmitoylethanolamide (PEA) is a physiologically active molecule that the body produces naturally in small amounts:
- PEA can be taken simultaneously with other medication
- Side effects are not common. Occasionally it can upset the gut.
- Use during pregnancy has not been studied. Discuss with your doctor.
- PEA does not contain sugar, yeast, allergens, sorbitol, magnesium stearate, salicylates.
Take 1 capsule daily at 8 pm for 3 days, then 1 capsule twice a day (8 am and 8 pm) for 3 days, then go up to 3 capsules a day (one at 8 am and two at 8 pm), most people need 4 x 300mg per day (two at 8am and 8pm). Take with or after food, or sprinkle or mix the contents of the capsule on your food.
In the case of severe pain, migraine etc. it is recommended that the capsule be opened and the contents (PEA) placed under the tongue for a few minutes. The PEA dissolves in the mouth and is absorbed sublingually.
If there is no improvement in pain intensity after a month then the daily amount taken can be doubled. Doses up to 16 capsules (100mg/kg body weight/day) can be taken.
PEA may take time to reduce pain and maximum pain reduction may take up to 3 months.
Compare the effect of Palmitoylethanolamide (PEA) versus ibuprofen, which is a nonsteroidal anti-inflammatory drug (NSAID) used for pain relief in the temporo-mandibular joint (TMJ), osteoarthritis or arthralgia. Pain decreases after 1 to 2 weeks of treatment is better with PEA than ibuprofen.
Palmitoylethanolamide (PEA) has been demonstrated to bind to a receptor in the cell nucleus. PEA performs a great variety of biological functions related to chronic and neuropathic pain and inflammation, as demonstrated in clinical trials. These include peripheral neuropathies such as diabetic neuropathy, chemotherapy-induced peripheral neuropathy, carpal tunnel syndrome, sciatic pain, osteoarthritis, low back pain, failed back surgery syndrome, dental pains, neuropathic pain in stroke and multiple sclerosis, chronic pelvic pain, post-herpetic neuralgia, and vaginal pains.
As PEA is an endogenous modulator as well as a compound in food, such as eggs and milk, no serious side effects have been reported, nor have any drug-drug interactions been reported.
PEA has been used by over a million people, showing the potential efficacy and safety in the treatment of various syndromes associated with chronic pain that is poorly responsive to standard therapies.
It can be used synergistically with other pain treatments and has been shown to reduce the reliance on opioid analgesics.
Other benefits:
- PEA is the key to suppressing overactive mast cells. Mast cells release inflammatory histamine and cytokines into the body. The analgesic and anti-inflammatory nutraceutical PEA holds great promise, blunting the inflammatory response in the treatment of chronic pain states like interstitial cystitis, bladder pain and irritable bowel syndrome.
- PEA may be reconsidered by clinicians, for its immune enhancing effect, as a new treatment modality for flu and respiratory infections due to its documented efficacy and lack of side effects.
- The neuro-protective effects of PEA are in part the result of its effects on down regulating the inflammatory cascade. Many neurodegenerative diseases are associated with a strong inflammatory component, such as Alzheimer’s disease, Parkinson’s disease or Multiple Sclerosis.
- PEA is an endocannabinoid, modulating the glia through the CBD2 receptor.
- People may feel better on PEA, including improvement in their mood.
Reference:
Palmitoylethanolamide, a neutraceutical, in nerve compression syndromes: efficacy and safety in sciatic pain and carpal tunnel syndrome by Keppel Hesselink Jan M, Kopsky David J, J Pain Res, 2015; 8: 729–734.
Acknowledgement: Painless clinic
Available for purchase
Painless Clinic: Unit 5,136 Railway St Cottesloe 1300 429 411
Fremantle Central Compounding Pharmacy: 1 Queen St & Cantonment St, Fremantle WA 6160 Phone: (08) 93352786
All 777 Compounding Pharmacies (Please note all other 777 pharmacies will supply within 48hours)
Captain Stirling Highway Compounding Pharmacy: 90 Stirling Hwy, Nedlands. WA Ph: (08) 9386 3380
Oxford Compounding Chemist: 73 Angove St, North Perth WA 6006 Phone: (08) 9225 9400
Pharmacy Help Mandurah Inside Peel Health: 110 Lakes Rd Mandurah 6210 Phone: (08) 95814833
Albany: Chester Pass Albany 160 Chester Pass Rd, Albany, WA, 6330 P: (08) 9841 3841
Queensland: The compounding lab: Email: enquiries@compoundinglab.com.au Phone: (07) 3862 6000